Chemical Abortion

Pro-lifers recognize surgical abortion as killing humans, but not all of them recognize the scope of the problem presenting as chemical abortion. Generally we  recognize  mifepristone, the chemical formerly known as RU-486. The initial name of the drug  stayed with us, (the same as with the Artist formerly known as Prince).  Mifepristone is best known in the U.S. for its labeled function to kill unborn humans during the embryonic stage, up to 49 days of pregnancy, (63 days at planned parenthood), although it has other investigational uses.

Meet the TWINS!  Ulipristal acetate and Mifepristone.  As you can see, they’re not quite identical, but very close. Both are selective progesterone receptor modulators.

Mifepristone, RU-486 is the most regulated drug in the U.S. Pharmacists don’t dispense it. It’s supposed to be dispensed only by physicians, directly to patients. In China and other countries it has been used as a morning after pill, as well as a killer of later embryos and early fetuses.

Those astute drug companies knew that this drug would not sell as a morning after pill in the U.S. That’s why we have it’s TWIN, Ulipristal Acetate, approved  by the FDA  in August , 2010,  and brought to us in by Watson Pharmaceuticals in December of the same year.  Watson also distributes Next Choice, generic of the original form of Plan B.

At 0.5mg/kg, Ulipristal Acetate, marketed as ELLA, is usable as a morning after pill. It’s marketed as an inhibitor of ovulation, but the manufacturer admits that the operative mechanism depends on the timing of its use. Like RU-486, Ulipristone is an anti-progesterone. It stops the action of that hormone in the reproductive tract, inhibits proliferation of the endometrium, inhibits implantation, and kills the embryo.

When used as a morning after pill Ella accomplishes this very early, before implantation. At higher doses, this drug can kill later embryos and fetuses just like its twin mifepristone.

In many states, pharmacists and hospitals will be required to distribute Ulipristal acetate, in the same way that they are now forced to dispense Plan B, levonorgestrel, the other morning after pill. Ella is among the drugs recommended for free distribution under the upcoming Obamacare, which will exacerbate complicity of all tax payers with chemical abortion, and add to the problems of conscientiously objecting health care workers.

Women can also visit to get Ella. It’s possible for them to fill out a questionnaire for ONLINE PRESCRIBING, (allowed by Utah state law) then have the drug dispensed to them. They can dial 855-2ELLARX and accomplish the same thing.

Ulipristal acetate is available for market as 30 mg tablets.  This supplies 0.5mg per kg for women up to 60 kg, or 132 lbs.  As you know, many ladies are bigger than that,  (including the author) and so the drug cannot expected to be uniformly effective throughout the American female population.  A 120mg dose is required to reliably inhibit ovulation according to the CHMP assessment report. 300mg is needed to kill more developed embryos and fetuses.

The convenience of obtaining Ulipristal acetate online  allows  the accumulation of doses needed to perform home chemical abortions which may be completed at hospitals if necessary.  Abortionist James Pendergraft supplied a model of initiating procedures by injecting the fetus, and allowing hospitals to complete the job.  All of this has been done before.

Even in medical journals you will see claims that the mechanism of Ella is to prevent ovulation, even when the data shows otherwise.   However the CHMP assessment available from Europe, where they do not have to lie to sell the drug, is much more matter of fact regarding the pharmacology of this drug.

Ulipristal acetate prevents progesterone from occupying its receptor, thus the gene transcription normally turned on by progesterone is blocked, and the proteins necessary to begin and maintain pregnancy are not synthesized.”

The quality of ulipristal acetate which brought it under consideration for drug development as a morning after pill is candidly given in the same report:

“Since progesterone is critical for implantation, it was thought that ulipristal acetate may have promise as a contraceptive agent.”

First born  twin, Mifepristone,  can only be obtained directly from Danco Laboratories  by clicking HERE, or by dialing 877-432-7596.    Only physicians may distribute this drug, and there are specific requirements to adequately inform patients concerning this form of abortion procedure,  use  a patient consent form, and keep records.

The FDA approved usage of mifepristone involves an oral dose of  three  200mg tablets.  Planned Parenthood apparently likes variety, and has experimented with cost containment by using lower doses, and the vaginal route of delivery.  Deaths from Clostridium sordellii infection have  inspired  a return to oral administration of the drug.  The procedure requires an initial physician visit for dispensing the drug,  a return visit in three days to receive  400mcg of misoprostil to cause expulsion of the dead human embryo, and a third visit at 14 days to ensure success.  About 8 percent of patients require a followup surgical abortion.

[2013] See Delgado and Davenport article: Progesterone use to reverse the effects of mifepristone.  4 of 6 women carried pregnancies to term after attempts to reverse mifepristone (prior to misoprostil administration) using 200mg of progesterone I.M.

Methotrexate is used in chemical abortion at  a dose of 50mg /square meter, injected intramuscularly. Alternatively a 50mg dose can be given orally.  This dose is followed on day 3 up to day 7  by a 800mcg vaginal dose  of misoprostil to expel the dead embryo.  A followup visit with the physician is needed to determine if the abortion is successful.   There are multiple possbilities for followup treatment should the abortion not be complete at the second visit, some involving a second dose of misoprostil, others involving surgical abortion.

Methotrexate is usually used as an anti-cancer drug.  It’s mechanism is to interrupt folic acid metabolism (by dihydrofolate reductase)  to the active form, which serves to block thymidine production, thereby  inhibiting  DNA synthesis and cell division.  As an abortion drug, it  causes degeneration of the  trophoblast, the tissue surrounding the embryo which produces the placenta. The production of HCG stops, which leads to a decline in progesterone production by the corpus luteum.  The uterine lining degenerates, and nutritional support for the embryo ceases.

Plan B One-Step, the over-the-counter morning after pill is 1.5mg of levonorgestrel, a  synthetic progestin.

From the Prescribing information of Plan B One-Step:

12.1 Mechanism of Action
Emergency contraceptive pills are not effective if a woman is already pregnant. Plan B One-Step is believed to act as an emergency contraceptive principally by preventing ovulation or fertilization (by altering tubal transport of sperm and/or ova). In addition, it may inhibit implantation (by altering the endometrium). It is not effective once the process of implantation has begun.

Note  the fact that levonorgestrel affects the endometrium and may act to inhibit implantation.  This stops the life of a human embryo at the blastocyst stage of development, and is one of the bases for controversy concerning dispensing and use of this form of birth control.  Unmentioned in the package insert is that effect on tubal transport also influences the transport of the very early embryo prior to implantation. 

Here’s the quote of the year concerning Plan B:

“It has more than doubled since the last time the data were collected,” said Megan L. Kavanaugh, a senior research associate at the Guttmacher Institute in New York who worked on the study.

However, she said in an interview, “its use still seems relatively low, given that it’s easy to access. So there’s room for improvement.”

Somehow, in the fevered brain of Ms. Kavanaugh  it represents an improvement to fail in the more reliable forms of preventing pregnancy, and require the use of the LEAST reliable modality, the morning after pill, tossed over the counter by the local pharmacist, who could be  censured for attempting to ascertain  clinically appropriate application of the drug.   Kavanaugh credits the media, and not health care professionals, for stimulating the increase in this dependency.  (A tiny silver lining in this cloud.)

Neither Plan B  One-Step nor Ella One are very effective.  In actual use, expect a failure rate of about 40 percent, in round numbers.  Cumulative failure rate for repeat users guarantees good business for the abortionists, and  this helps to  fulfill the marketing plans of of such entities as  Planned Parenthood.  Plan B shares Ella’s problem of being even less effective in the larger set of women.

Discouraging the use of chemical abortifacients  by means of legal regulation is a difficult and expensive task.   The  proposed legislation to require reporting of mifepristone adverse events is a good start, and opposition from the abortion industry is certain.   One might evaluate the potential efficacy of this and future  regulations by how loudly  the abortion providers  protest.

Overall the abortion problem is most efficiently tackled  by prohibiting government funds for both chemical and surgical abortions, requiring full disclosure of drug information to the patients, and protecting the option of all health care employees to refuse participation.

It should be remembered that all hormonal birth control forms have the possibility to act in a manner that causes inhibition of implantation. As with Plan B, this information can be found in the prescribing information for each drug.

The availability of artificial birth control  has not produced a decrease in demand for abortion.  It is a failed social experiment.

Innovation and invention are largely in response to filling human needs and alleviating suffering.  The practice of killing unwanted or disabled human beings will impede further medical and technological advances, and lead to a DEvolution of civilization and the human species.

It’s heartening  to see the recent pro-life legislative efforts in Indiana, and this pharmacist remains available to provide information and assistance if needed.

Useful Links

Ella Vs Plan B – study by Anna Glasier

The European Medicines Agency CHMP Assessment Report for Ulipristal acetate – contains the most useful information from the manufacturer on the scientific basis and rationale for developing this compound as a morning after pill.

New Morning After Pill Works When Taken 5 Days After Intercourse … SOMEWHAT.

Useful Information About Ella from Tech News Site

Revelations from the  European CHMP Report on Ulipristal Acetate

FDA Approves Ulipristal Acetate as expected

Updated FDA summary of mifepristone related adverse events.

A Model for the  Ulipristal Acetate Abortions

Prescriber information for Mifeprex (RU486)

Methotrexate abortion protocol from National Abortion Federation

Methotrexate plus misoprostil efficacy

Pharmacist Error: Methotrexate dispensed to Pregnant Woman

Methotrexate: hostile abortion attack reversed by leucovorin rescue.

Teratogen Update: Methotrexate

Prescriber information for Plan B One-Step

Emergency Contraception does not reduce abortion rates.

Failed Social Experiment

Effort to Identify Women for whom Morning After Pills do Not Work – Anna Glasier

Spanish study: trends in use of contraception and voluntary abortion 1997-2007

Abortion on Rise in Sweden despite availability of morning after pill.

Selling the Pill

Indiana House Bill 1258, regulation of RU-486. Introduced by Rep. Bob Morris. 

Indiana Senate Bill 72    this version lacks requirements for  the reporting of adverse events arising from use of abortion drugs.   This further enables misrepresentation of the risk of pregnancy vs abortion, as there is no impetus for an abortionist to report adverse events associated with abortion surgery or drugs.

Indiana House Bill 1228,  Conscience protection for health professionals, introduced by Steve Davisson,

 Planned Parenthood Financial Report 2010: Your Tax Dollars at Work

FDA summary of Mifepristone (RU486)  Adverse events.

Plan B does Not Work Well for Big Girls

Progesterone Use to Reverse Effects of Mifepristone

The Post Ovulatory Mechanism of Plan B, Peck and Velez 2013

New Studies show that All Morning After Birth Control Can Cause Early Abortion. Lozier Institute Review, 2014

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